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PRL-8-53
- Cholinergic
- Potentiates dopamine.
- Partially inhibiting serotonin.
- PRL-8-53 reverses the catatonic and ptotic effects of reserpine.
- Oral LD50 in mice of 860 mg/kg
- Doses above 8 mg/kg have brief hypotensive effects in canines.
- High doses depress motor activity in the rat and mouse, with the ED50 for a 50% reduction in motor activity of mice at 160 mg/kg.
- PRL-8-53 displays spasmolytic effects.